Mesoblast Limited

 ASX:MSB ISIN:AU000000MSB8

May 26, 2012

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Mesoblast Limited Company Summary

 Mesoblast Limited (ASX:MSB) (OTC ADR: MBLTY) is the world's leading developer of innovative biological products for the broad field of regenerative medicine.

Mesoblast's commercial strategy is based on its unique proprietary adult mesenchymal precursor cells.

The company's lead products will target cardiovascular conditions, diabetes, inflammatory conditions of lungs and joints, eye diseases, bone marrow cancers, bone fractures, cartilage degeneration and musculoskeletal conditions.

Mesoblast and global biopharmaceutical company Cephalon Inc. have established a strategic alliance to commercialize adult stem cell products for degenerative conditions of the cardiovascular and central nervous systems. The alliance also extends to products for augmenting bone marrow transplantation in cancer patients.
 

DIRECTORS / OFFICERS

 
Brian Jamieson FCA
Non-Executive Chairman
Brian Jamieson was Chief Executive of Minter Ellison Melbourne and a partner of the Minter Ellison Revenue Group from 2002-2005. He retired as Chief Executive of Minter Ellison Melbourne on 31 December 2005. Prior to joining Minter Ellison, Mr Jamieson was Executive Officer at KPMG from 1998-2000, Managing Partner of KPMG Melbourne and Southern Regions from 1993-1998 and Chairman of KPMG Melbourne from 2001-2002. He was also a KPMG Board Member in Australia , and a member of the USA Management Committee.
Donal O'Dwyer, BE, MBA
Non-Executive Deputy Chairman
Mr O'Dwyer has almost 20 years experience as a senior executive in the global cardiovascular and medical devices industries. From 2000 to 2003, he was worldwide president of Cordis Cardiology, the cardiology division of Johnson & Johnson's Cordis Corporation. Cordis is the world's largest manufacturer of innovative products for interventional medicine, minimally invasive computer-based imaging, and electrophysiology. In this role, Mr O'Dwyer led Cordis through the launch of the revolutionary Cypher drug eluting coronary stent technology, and saw the company take over number one market share of coronary stents worldwide.
Professor Silviu Itescu, MBBS (Hons), FRACP, FACP, FACR
Director and Chief Scientific Adviser
Professor Itescu is the Founder of Mesoblast Limited and Angioblast Systems, Inc. Most recently Director of Transplantation Immunology at New York 's Columbia University Medical Center , Professor Itescu has established an outstanding international reputation in the fields of stem cell biology, autoimmune diseases, organ transplantation and heart failure. His experiences range from laboratory research to new drug development and clinical evaluation. Professor Itescu pioneered novel approaches to the use of adult stem cells for the treatment of heart disease and is leading international collaborative trials in this area.
Michael Spooner, BCom, ACA, MAICD
Non-Executive Director
Mr Spooner has an extensive network of relationships with investment firms and business communities across the globe, having spent the majority of the past 25 years living and working internationally. He has an outstanding track record in the rapid international commercialisation of high growth companies including within the medical application and commercial technology sectors. Most recently, Mr Spooner was Managing Director & CEO of Ventracor Limited where he led the transformation of a small Australian listed life sciences company into the second highest performing stock on the S&P/ASX 200 index in 2003.
Byron McAllister, B.Sc, M.Ag
Non-Executive Director
Mr McAllister has extensive expertise in product development, quality assurance, and obtaining FDA regulatory approvals within the healthcare industry. He has extensive expertise within the biologics, pharmaceutical, and medical device industries, and has prepared full documentation for approval by the U.S. FDA, UK MCA, and other world health regulatory authorities. Most recently, Mr McAllister has served as Vice President, Worldwide Quality Assurance, for the Ares-Serono Group based in Geneva and Boston , overseeing operations in over a dozen countries. Mr McAllister has held senior management positions in manufacturing and quality assurance with Abbott Laboratories' Ross Laboratories and Diagnostics Divisions, Amersham Corporation, and Coulter Electronics Corporation.
Kevin Hollingsworth, FCPA, FCMA
Company Secretary
Mr. Hollingsworth is a certified public accountant, and a past chairman of both the National and Victorian Industry and Commerce Accountants Committees. Mr. Hollingsworth has most recently been non-executive director and company secretary for Alpha Technologies Corporation Ltd, a global company with operations in the US, Mexico and China, designing and manufacturing temperature sensors for disposable medical devices, as well as precision thermometry and instrumentation for the biotechnical and life science industry.
 

ANNUAL REPORT

 
 

PRESENTATIONS

 
 
 

COMPANY DATA

 
Company Headquarters Level 39 
    55 Collins Street 
    Melbourne 3000  
    AUSTRALIA 
Company Telephone +61-3-9639-6036 
Company Fax +61-3-9369-6030 
Company Principal Sector Health & Pharm 
Company Principal Industry Biotechnology 
Company Listed 2004/12/16 
Company Homepage www.mesoblast.com
 

Key Developments: Mesoblast Limited
 Mesoblast Limited (ASX:MSB) FDA Clearance for Phase 2 Clinical Trial in Type 2 Diabetes
JAN 31, 2012 11:09 - Article Views: 434
Mesoblast Limited (ASX:MSB) today announced that it has received clearance from the United States Food and Drug Administration (FDA) to begin a Phase 2 clinical trial of its proprietary adult stem cells for the treatment of Type 2 diabetes.
 Corporate Strategy Key to Mesoblast Limited (ASX:MSB) Success
NOV 24, 2011 11:24 - Article Views: 978
Mesoblast Limited (ASX:MSB) Chief Executive, Professor Silviu Itescu, today provided shareholders at Mesoblast's Annual General Meeting with an overview of the company's corporate strategy and major highlights of recent achievements.
 Mesoblast Limited (ASX:MSB) 2011 Chairman's Address and CEO's Presentation to Shareholders
NOV 24, 2011 09:48 - Article Views: 1,043
Mesoblast Limited (ASX:MSB) Chairman's Address and CEO's Presentation to Shareholders
 Positive Outcome From FDA Meeting For Type 2 Diabetes Clinical Program Using Intravenous Delivery of Mesoblast Limited (ASX:MSB) Proprietary Adult Stem Cells
NOV 22, 2011 10:08 - Article Views: 1,124
Global regenerative medicine company, Mesoblast Limited (ASX:MSB), today announced that it has reached agreement with the United States Food and Drug Administration (FDA) on the key elements of the company's first clinical trial using intravenous delivery of its proprietary allogeneic, or off-the-shelf, mesenchymal precursor cell (MPC) technology in patients with Type 2 Diabetes. Based on the positive outcome of the FDA meeting held on November 18, Mesoblast will file an Investigational New Drug (IND) submission within the next 30-60 days to seek clearance for patient recruitment.
 Mesoblast Limited (ASX:MSB) Presented Positive Results from Phase 2 Trial of Adult Stem Cell Therapy at the American Heart Association Annual Meeting
NOV 15, 2011 08:25 - Article Views: 883
Regenerative medicine company Mesoblast Limited (ASX:MSB) today announced positive Phase 2 heart failure trial results of its allogeneic, or off-the-shelf, adult stem cell product Revascor(TM) after all patients had completed a minimum follow-up of 12 months, and a mean follow-up of 22 months. The Phase 2 trial results in 60 patients were presented at the American Heart Association annual meeting in Orlando, Florida, by the trial's independent principal investigator Dr Emerson C. Perin, Director of Research in Cardiovascular Medicine and Medical Director, Stem Cell Center, Texas Heart Institute in Houston.
 Mesoblast Limited (ASX:MSB) Reports Positive Results Using Intravenously Injected Adult Stem Cells for Type 2 Diabetes
NOV 10, 2011 08:27 - Article Views: 1,392
Regenerative medicine company, Mesoblast Limited (ASX:MSB), today announced that a single intravenous injection of its proprietary adult stem cells resulted in significant lowering of blood sugar levels for up to eight weeks in a controlled, randomized preclinical trial in non-human primates with Type 2 diabetes. This was accompanied by significant reductions in circulating inflammatory markers to levels associated with protection against heart attacks and death in patients with Type 2 diabetes. Results of the study were presented at the Credit Suisse Healthcare conference in Phoenix, Arizona.
 Mesoblast Limited (ASX:MSB) Cleared to Begin First Phase 2 Clinical Trial for Eye Diseases
OCT 24, 2011 09:48 - Article Views: 1,319
Regenerative medicine company Mesoblast Limited (ASX:MSB) (PINK:MBLTY) today announced that it has received regulatory clearance from the Singapore Health Sciences Authority (HSA) to commence the first Phase 2 trial of its proprietary allogeneic (off-the-shelf) adult stem cell therapy for patients with proliferation of leaky blood vessels in the eyes - neovascular ("wet") Age-related Macular Degeneration (AMD). Wet AMD causes sudden and severe central vision loss and accounts for approximately 90 percent of all blindness in the elderly. Mesoblast is developing a stem cell therapeutic product for treating various vascular diseases of the eye, including wet AMD and diabetic macular edema (DME).
 Mesoblast Limited (ASX:MSB) Received Licensing Executives Society 2011 Deals of Distinction(TM) Award
OCT 20, 2011 10:21 - Article Views: 1,146
Mesoblast Limited (ASX:MSB) and its strategic alliance partner Cephalon Inc. were today awarded the Licensing Executives Society (U.S.A. and Canada), Inc. 2011 Deals of Distinction(TM) Award. The award was conferred for the most compelling licensing and intellectual property-related deal in the life sciences sector.
 Mesoblast Limited (ASX:MSB) and Lonza Group (VTX:LONN) Form Strategic Global Manufacturing Alliance
SEP 27, 2011 08:27 - Article Views: 932
Global regenerative medicine company Mesoblast Limited (ASX:MSB) and Lonza Group (VTX:LONN), a world leader in biologic manufacturing, today announced that they have entered into a strategic alliance for clinical and long-term commercial production of Mesoblast's off-the-shelf (allogeneic) adult stem cell products.
 Mesoblast Limited (ASX:MSB) Receives Clearance To Begin First European Trial Of Allogeneic Or 'Off-The-Shelf' Stem Cell Treatment For Heart Attacks
SEP 5, 2011 08:36 - Article Views: 1,098
Global regenerative medicine company, Mesoblast Limited (ASX:MSB), today announced that it had received clearance from the European Medicines Agency (EMA) to begin a 225-patient multi-center Phase 2 clinical trial in Europe for its lead cardiovascular product Revascor(TM) in conjunction with angioplasty and stent procedures to prevent heart failure after a major heart attack. Revascor(TM) is an allogeneic, or "off-the-shelf", adult stem cell product derived from Mesoblast's proprietary Mesenchymal Precursor Cell (MPC) platform technology which is being developed for use in a range of cardiovascular diseases including congestive heart failure, chronic angina, and heart attacks.

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Company Reports

  • Mesoblast Limited (ASX:MSB) FORM 604 NOTICE OF CHANGE OF INTERESTS OF SUB HOLDER  Click to Download
  • Mesoblast Limited (ASX:MSB) Appendix 3B  Click to Download
  • Mesoblast Limited (ASX:MSB) Company Secretary Appointment/Resignation  Click to Download
  • Mesoblast Limited (ASX:MSB) Company Secretary Appointment/Resignation  Click to Download
  • Mesoblast Limited (ASX:MSB) Presentation to 30th JP Morgan Healthcare Conference in USA  Click to Download
  • Mesoblast Limited (ASX:MSB) FORM 604 NOTICE OF CHANGE OF INTERESTS OF SUB HOLDER  Click to Download
  • Mesoblast Limited (ASX:MSB) Results of Meeting  Click to Download
  • Mesoblast Limited (ASX:MSB) Presentation to the American Heart Association  Click to Download
  • Mesoblast Limited (ASX:MSB) Appendix 4C - quarterly  Click to Download
  • Mesoblast Limited (ASX:MSB) Appendix 4C - quarterly  Click to Download
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