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Sydney, Mar 21, 2011 (ABN Newswire) - Benitec Limited (
ASX:BLT) (PINK:BNIKF), a world leader in RNA-based gene silencing for human therapeutics, is pleased to acknowledge that the City of Hope research hospital in Duarte, California is planning to initiate a second small Phase I/II study using Benitec's DNA-directed RNA interference (ddRNAi) technology in lymphoma patients carrying the HIV virus. The aim of the study is to optimize the treatment by modifying a range of clinical parameters.
From 2007 to 2010, Benitec funded the initial clinical development by the City of Hope of an RNA-based HIV/AIDS therapeutic molecule, one component of which is based on its ddRNAi technology - namely a short hairpin (sh)RNA construct targeted at a specific HIV gene. The novel ddRNAi-based product candidate was taken into a Phase I/II pilot human clinical trial and produced promising interim results in terms of safety and proof of feasibility. The data was published in Science Translational Medicine in June 2010.
Whilst this new study is not being funded by Benitec, it utilizes the same therapeutic molecule, and a successful outcome will be of significant benefit to Benitec as it will provide further clinical evidence of the potential of Benitec's proprietary technology for human therapeutics in general, and HIV/AIDS specifically.
Commenting on the news, Dr Peter French, CEO of Benitec, said: "We welcome the news of this second clinical study to explore ways to improve the performance of the RNA construct in the HIV/AIDS setting. Like the City of Hope, we believe that results of our work to date justified the further development of a ddRNAi-based cell therapy platform for HIV. Benitec is seeking to partner an HIV program based on ddRNAi to build on the initial promise of that work. This further study being undertaken by the City of Hope should assist in that aim."
Details of the new clinical study were reported in genomeweb at http://www.genomeweb.com/rnai/city-hope-preps-second-study-expressed-rnai-aids-treatment
ASX:BLT) (PINK:BNIKF), a world leader in RNA-based gene silencing for human therapeutics, is pleased to acknowledge that the City of Hope research hospital in Duarte, California is planning to initiate a second small Phase I/II study using Benitec's DNA-directed RNA interference (ddRNAi) technology in lymphoma patients carrying the HIV virus. The aim of the study is to optimize the treatment by modifying a range of clinical parameters.From 2007 to 2010, Benitec funded the initial clinical development by the City of Hope of an RNA-based HIV/AIDS therapeutic molecule, one component of which is based on its ddRNAi technology - namely a short hairpin (sh)RNA construct targeted at a specific HIV gene. The novel ddRNAi-based product candidate was taken into a Phase I/II pilot human clinical trial and produced promising interim results in terms of safety and proof of feasibility. The data was published in Science Translational Medicine in June 2010.
Whilst this new study is not being funded by Benitec, it utilizes the same therapeutic molecule, and a successful outcome will be of significant benefit to Benitec as it will provide further clinical evidence of the potential of Benitec's proprietary technology for human therapeutics in general, and HIV/AIDS specifically.
Commenting on the news, Dr Peter French, CEO of Benitec, said: "We welcome the news of this second clinical study to explore ways to improve the performance of the RNA construct in the HIV/AIDS setting. Like the City of Hope, we believe that results of our work to date justified the further development of a ddRNAi-based cell therapy platform for HIV. Benitec is seeking to partner an HIV program based on ddRNAi to build on the initial promise of that work. This further study being undertaken by the City of Hope should assist in that aim."
Details of the new clinical study were reported in genomeweb at http://www.genomeweb.com/rnai/city-hope-preps-second-study-expressed-rnai-aids-treatment
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About Benitec Limited
Benitec Limited (ASX:BLT) (PINK:BNIKF) holds a dominant position in expressed RNA interference (RNAi)-based human therapeutics, with a transformational platform technology supported by a robust and extensive intellectual property portfolio. Benitec is leveraging this platform to develop and build a pipeline of expressed RNAi therapeutics focusing on treatment and alleviation of cancer and infectious disease. With strong global partnerships and committed scientific and clinical investigators, Benitec Ltd aims to deliver a range of novel RNAi-based therapeutics to the clinic in partnership with the pharmaceutical industry.
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